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Following the above general procedure E, the reaction was purified by flash-column chromatography on silica gel to provide the desired isopropyl 4-(adamantylamino)-3-(pyrimidin-5-ylmethyleneamino)benzoate (SRS15-80, Scheme 4) (90 mg, 0.215 mmol, 77%)

No added sugar - The product contains low-energy sweeteners, which contributes to the reduction of energy content of the preparation

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This disparity is hypothesized to arise from differences in estrogen-mediated neuroprotection, lifestyle factors, and occupational exposure to neurotoxins (Ben-Shlomo et al., 2024) (Figure 2)

3d and Extended Data Fig

Proper math prevents dosing errors that compound throughout the vial